She studied at Cambridge as an undergraduate but was not awarded a degree because the university didn’t grant degrees to women at that time. After meeting Harlow Shapley, the Director of the Harvard College Observatory, who had just begun began a graduate program in astronomy, she left England for the United States in 1923.

Payne-Gaposchkin became the first person to earn a Ph.D. in astronomy from Radcliffe (now part of Harvard). By studying the spectra of stars, Payne-Gaposchkin determined that hydrogen and helium were the most abundant elements in stars. She was the first woman to receive the rand of full professor at Harvard and also the first woman chairperson of a department at Harvard University.